Brand  (β version)

PDB ID: 3R30

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CD2 1-(2-aminoethyl)-3-[2-(quinolin-3-yl)pyridin-4-yl]-1h-pyrazole-5-carboxylic acid PoSSuM

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Structure summary

Code : 3R30   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : MK2 kinase bound to Compound 2
Release Data : 2011-05-25
Compound :
mol_id molecule chains synonym
1 MAP kinase-activated protein kinase 2 A MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2
ec: 2.7.11.1
fragment: Kinase domain, UNP residues 46-364
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPKAPK2
expression_system_strain: Tuner (DE3)
expression_system_vector_type: plasmid
Authors : Oubrie, A., Fisher, M.
Keywords : Kinase domain with bound inhibitor, Kinase domain, Phosphotransferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.20 Å )
Citation :

Structure-based lead identification of ATP-competitive MK2 inhibitors.

Barf, T.,Kaptein, A.,Wilde, S.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 3818 - 3822

PubMed: 21565500
DOI: 10.1016/j.bmcl.2011.04.018

Reaction

Chain : A
UniProt : P49137 (MAPK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:12171911, PubMed:8774846
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:12171911, PubMed:8774846
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