Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CD2 1-(2-aminoethyl)-3-[2-(quinolin-3-yl)pyridin-4-yl]-1h-pyrazole-5-carboxylic acid
Code : 3R30
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : MK2 kinase bound to Compound 2
Release Data : 2011-05-25
Compound :
mol_id molecule chains synonym
1 MAP kinase-activated protein kinase 2 A MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2
ec: 2.7.11.1
fragment: Kinase domain, UNP residues 46-364
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPKAPK2
expression_system_strain: Tuner (DE3)
expression_system_vector_type: plasmid
Authors : Oubrie, A., Fisher, M.
Keywords : Kinase domain with bound inhibitor, Kinase domain, Phosphotransferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.20 Å )
Citation :

Structure-based lead identification of ATP-competitive MK2 inhibitors.

Barf, T.,Kaptein, A.,Wilde, S.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 3818 - 3822

PubMed: 21565500
DOI: 10.1016/j.bmcl.2011.04.018

Chain : A
UniProt : P49137 (MAPK2_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.