PDB ID: 3R0T
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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EDO | 1,2-ethanediol | PoSSuM | |||
FU9 | 3-(cyclopropylamino)-5-{[3-(trifluoromethyl)phenyl]amino}pyrimido[4,5-C]quinoline-8-carboxylic acid | PoSSuM | |||
PEG | Di(hydroxyethyl)ether | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 3R0T
Structure summary
Code : | 3R0T PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-5279 | ||||||||||||
Release Data : | 2011-12-07 | ||||||||||||
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Authors : | Battistutta, R., Papinutto, E., Lolli, G., Pierre, F., Haddach, M., Ryckman, D.M. | ||||||||||||
Keywords : | Kinase, CK2-inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.7500 Å ) | ||||||||||||
Citation : |
Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Battistutta, R.,Cozza, G.,Pierre, F.
et al.
PubMed: 21870818 Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2.
Cozza, G.,Mazzorana, M.,Papinutto, E.
et al.
PubMed: 19432557 |
Reaction
Chain : | A | ||||||||||||||
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UniProt : | P68400 (CSK21_HUMAN) | ||||||||||||||
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