Brand  (β version)

PDB ID: 3R0I

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Ligands
Code Name Style Show Link
C0K {(1s)-1-(3,4-difluorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3R0I   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/ANTIBIOTIC
Title : IspC in complex with an N-methyl-substituted hydroxamic acid
Release Data : 2011-09-07
Compound :
mol_id molecule chains synonym
1 1-deoxy-D-xylulose 5-phosphate reductoisomerase A,B DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase
ec: 1.1.1.267
Source :
mol_id organism_scientific expression_system
1 Escherichia coli K-12  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: dxr, ispC, yaeM, b0173, JW0168
Authors : Behrendt, C.T., Kunfermann, A., Illarionova, V., Matheeussen, A., Pein, M.K., Graewert, T., Bacher, A., Eisenreich, W., Illarionov, B., Fischer, M., Maes, L., Groll, M., Kurz, T.
Keywords : antimalarial agents, inhibitors, IspC, non-mevalonate pathway, Rossmann Fold, Reductoisomerase of Desoxy-xylulose-5P to Methyl-erythritol-3P, NADPH, Mn, reverse hydroxamic acid ligand binding, cytosol, OXIDOREDUCTASE-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr).

Behrendt, C.T.,Kunfermann, A.,Illarionova, V.  et al.
(2011)  J.Med.Chem.  54 : 6796 - 6802

PubMed: 21866890
DOI: 10.1021/jm200694q

Reaction

Chain : A, B
UniProt : P45568 (DXR_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH 1.1.1.267 PubMed:10631325, PubMed:10787409, PubMed:9707569
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