PDB ID: 3QTF
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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05S | (6s)-6,15,15,18-tetramethyl-17-oxo-2,3,4,5,6,7,14,15,16,17-decahydro-1h-8,12-(metheno)[1,4,9]triazacyclotetradecino[9,8-a]indole-9-carboxamide | PoSSuM | |||
DMS | Dimethyl sulfoxide | PoSSuM |
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Download interaction data: 3QTF
Structure summary
Code : | 3QTF PDBj RCSB PDB PDBe | ||||||||||||
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Header : | CHAPERONE/CHAPERONE INHIBITOR | ||||||||||||
Title : | Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity | ||||||||||||
Release Data : | 2011-04-06 | ||||||||||||
Compound : |
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Authors : | Zapf, C.W., Bloom, J.D., McBean, J.L., Dushin, R.G., Nittoli, T., Ingalls, C., Sutherland, A.G., Sonye, J.P., Eid, C.N., Golas, J., Liu, H., Boschelli, F., Hu, Y., Vogan, E.M., Levin, J.I. | ||||||||||||
Keywords : | Chaperone, ATP binding domain, ATP-binding, Nucleotide-binding, Phosphoprotein, Stress response, CHAPERONE-CHAPERONE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.5703 Å ) | ||||||||||||
Citation : |
Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.
Zapf, C.W.,Bloom, J.D.,McBean, J.L.
et al.
PubMed: 21420297 |
Reaction
Chain : | A | ||||||||
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UniProt : | P07900 (HS90A_HUMAN) | ||||||||
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