Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CUF [2,2'-{(4,5-difluorobenzene-1,2-diyl)bis[(nitrilo-kappan)methylylidene]}bis{5-[2-(piperidin-1-yl)ethoxy]phenolato-kappao}(2-)]copper (II)
K Potassium ion
Modified Residues
Code Name Link
BRU 5-bromo-2'-deoxyuridine-5'-monophosphate
Code : 3QSC
Header : DNA
Title : The first crystal structure of a human telomeric G-quadruplex DNA bound to a metal-containing ligand (a copper complex)
Release Data : 2011-12-07
Compound :
mol_id molecule chains
1 5'-D(*AP*GP*GP*GP*TP*(BRU)P*AP*GP*GP*GP*TP*T)-3' X
other_details: Human telomeric G-quadruplex DNA
Source :
mol_id organism_scientific
1
synthetic: yes
other_details: This sequence occurs naturally in humans
Authors : Campbell, N.H., Abd Karim, N.H., Parkinson, G.N., Vilar, R., Neidle, S.
Keywords : Parallel, telomere, quadruplex, drug, DNA, metal complex, copper complex
Exp. method : X-RAY DIFFRACTION ( 2.4000 Å )
Citation :

Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes.

Campbell, N.H.,Karim, N.H.,Parkinson, G.N.  et al.
(2012)  J.Med.Chem.  55 : 209 - 222

PubMed: 22112241
DOI: 10.1021/jm201140v