Het-PDB Navi2 (PDB: 3QRK)

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Ligands
Code	Name		Style	Show	Link
9DP	(3s)-6-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]amino}-1h-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3QRK

Code :

3QRK PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

The crystal structure of human abl1 kinase domain in complex with DP-987

Release Data :

2011-06-01

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase ABL1	A	Abelson murine leukemia viral oncogene homolog 1, Proto-oncogene c-Abl, p150
	ec: 2.7.10.2 fragment: Kinase domain, UNP residues 229-499

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	SPODOPTERA FRUGIPERDA (taxid:7108)
	gene: ABL1, ABL, JTK7 expression_system_common: FALL ARMYWORM expression_system_strain: SF9 expression_system_cell_line: SF9 expression_system_vector_type: BACULOVIRUS

Authors :

Chan, W.W., Wise, S.C., Kaufman, M.D., Ahn, Y.M., Ensinger, C.L., Haack, T., Hood, M.M., Jones, J., Lord, J.W., Lu, W.P., Miller, D., Patt, W.C., Smith, B.D., Petillo, P.A., Rutkoski, T.J., Telikepalli, H., Vogeti, L., Yao, T., Chun, L., Clark, R., Evangelista, P., Gavrilescu, L.C., Lazarides, K., Zaleskas, V.M., Stewart, L.J., Van Etten, R.A., Flynn, D.L.

Keywords :

ABL1, KINASE, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036.

Chan, W.W.,Wise, S.C.,Kaufman, M.D. et al.
(2011) Cancer Cell 19 : 556 - 568

PubMed: 21481795
DOI: 10.1016/j.ccr.2011.03.003

Chain :

UniProt :

P00519 (ABL1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:20357770, PubMed:28428613
	-	PROSITE-ProRule:PRU10028, PubMed:20357770, PubMed:28428613

PDB ID: 3QRK

Hetero Atom Contents

Structure summary

Reaction