Het-PDB Navi2 (PDB: 3Q32)

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Ligands
Code	Name		Style	Show	Link
J2I	2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Modification
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Download interaction data: 3Q32

Code :

3Q32 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Structure of Janus kinase 2 with a pyrrolotriazine inhibitor

Release Data :

2011-02-16

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK2	A,B	Janus kinase 2, JAK-2
	ec: 2.7.10.2 fragment: protein kinase 2 domain (UNP residues 839-1132)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK2 expression_system_cell_line: SF9 expression_system_vector_type: baculovirus

Authors :

Sack, J.S.

Keywords :

ATP-binding, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Pyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3.

Harikrishnan, L.S.,Kamau, M.G.,Wan, H. et al.
(2011) Bioorg.Med.Chem.Lett. 21 : 1425 - 1428

Chain :

A, B

UniProt :

O60674 (JAK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:7615558, PubMed:9618263
	-	PROSITE-ProRule:PRU10028, PubMed:7615558, PubMed:9618263

PDB ID: 3Q32