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Ligands
Code Name Style Show Link
JWS 2-(4,6-diamino-1,3,5-triazin-2-yl)-4-methoxyphenol
PO4 Phosphate ion
Non-standard Residues
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Glycosylation
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Code : 3PXY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : CDK2 in complex with inhibitor JWS648
Release Data : 2011-02-16
Compound :
mol_id molecule chains synonym
1 Cell division protein kinase 2 A CDK2, p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDK2
expression_system_strain: TUNER(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pGEX6P-1
Authors : Han, H., Betzi, S., Alam, R., Schonbrunn, E.
Keywords : protein kinase, CDK2, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Discovery of a Potential Allosteric Ligand Binding Site in CDK2.

Betzi, S.,Alam, R.,Martin, M.  et al.
(2011)  Acs Chem.Biol.  6 : 492 - 501

PubMed: 21291269
DOI: 10.1021/cb100410m

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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