Brand  (β version)

PDB ID: 3PX8

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Ligands
Code Name Style Show Link
JP2 2-amino-4-oxo-1,4-dihydropteridine-7-carboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3PX8   PDBj   RCSB PDB   PDBe
Header : hydrolase/inhibitor
Title : RTA in complex with 7-carboxy-pterin
Release Data : 2011-06-22
Compound :
mol_id molecule chains
1 Preproricin X
fragment: UNP residues 18-275
Source :
mol_id organism_scientific organism_common expression_system
1 Ricinus communis  (taxid:3988) Castor bean Escherichia coli  (taxid:562)
expression_system_strain: JM101
expression_system_vector_type: plasmid
expression_system_plasmid: pUTA
Authors : Jasheway, K.R., Robertus, J.D.
Keywords : Ricin, toxin, protein-ligand complex, hydrolase, ribosome inactivating protein, N-glycosidase, pterin, hydrolase-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.2900 Å )
Citation :

7-Substituted pterins provide a new direction for ricin A chain inhibitors.

Pruet, J.M.,Jasheway, K.R.,Manzano, L.A.  et al.
(2011)  Eur.J.Med.Chem.  46 : 3608 - 3615

PubMed: 21641093
DOI: 10.1016/j.ejmech.2011.05.025

Reaction

Chain : X
UniProt : D6MWP9 (D6MWP9_RICCO)
Reaction: EC: Evidence:
Physiological Direction:
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. 3.2.2.22 ARBA:ARBA00000237
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