Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0G7 D-phenylalanyl-N-[(3s)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide
MAN Alpha-D-mannose
NAG N-acetyl-D-glucosamine
Modified Residues
Code Name Link
TYS O-sulfo-L-tyrosine
Code : 3PMH
Header : blood cloting, hydrolase/inhibitor
Title : Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites
Release Data : 2011-06-01
Compound :
mol_id molecule chains synonym
1 THROMBIN ALPHA-CHAIN A Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains synonym
2 THROMBIN BETA-CHAIN B Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains
3 Platelet glycoprotein Ib alpha chain G
fragment: unp residues 17-306
mutation: C65A
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
other_details: From human plasma
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
other_details: From human plasma
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Drosophila melanogaster  (taxid:7227)
gene: GP1BA, platelet glycoprotein Ib alpha
Authors : Varughese, K.I., Celikel, R.
Keywords : Sulfated tyrosine residues, Leucine Rich Repeats, Protease Platelet receptor of thrombin, Thrombin binding, Platelet surface, blood cloting, hydrolase-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 3.20 Å )
Citation :

Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.

Zarpellon, A.,Celikel, R.,Roberts, J.R.  et al.
(2011)  Proc.Natl.Acad.Sci.USA  108 : 8628 - 8633

PubMed: 21555542
DOI: 10.1073/pnas.1017042108

Chain : B
UniProt : P00734 (THRB_HUMAN)
Reaction : Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Chain : G
UniProt : P07359 (GP1BA_HUMAN)
Reaction : -