Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
027 7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1h-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2h)-one
Code : 3PIX
Header : TRANSFERASE/INHIBITOR
Title : Crystal structure of BTK kinase domain complexed with 2-Isopropyl-7-(4-methyl-piperazin-1-yl)-4-(5-methyl-2H-pyrazol-3-ylamino)-2H-phthalazin-1-one
Release Data : 2011-01-12
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase BTK A Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase
ec: 2.7.10.2
fragment: unp residues 387-659
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: AGMX1, ATK, BPK, BTK
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
Authors : Kuglstatter, A., Wong, A.
Keywords : helix C-out, DFG-in, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.

Kuglstatter, A.,Wong, A.,Tsing, S.  et al.
(2011)  Protein Sci.  20 : 428 - 436

PubMed: 21280133
DOI: 10.1002/pro.575

Chain : A
UniProt : Q06187 (BTK_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.