Het-PDB Navi2 (PDB: 3PIX)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
027	7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1h-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2h)-one				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 3PIX

Code :

3PIX PDBj RCSB PDB PDBe

Header :

TRANSFERASE/INHIBITOR

Title :

Crystal structure of BTK kinase domain complexed with 2-Isopropyl-7-(4-methyl-piperazin-1-yl)-4-(5-methyl-2H-pyrazol-3-ylamino)-2H-phthalazin-1-one

Release Data :

2011-01-12

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase BTK	A	Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase
	ec: 2.7.10.2 fragment: unp residues 387-659

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: AGMX1, ATK, BPK, BTK expression_system_common: Fall armyworm expression_system_cell_line: SF9 expression_system_vector_type: BACULOVIRUS

Authors :

Kuglstatter, A., Wong, A.

Keywords :

helix C-out, DFG-in, TRANSFERASE, TRANSFERASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.85 Å )

Citation :

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.

Kuglstatter, A.,Wong, A.,Tsing, S. et al.
(2011) Protein Sci. 20 : 428 - 436

Chain :

UniProt :

Q06187 (BTK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:11606584, PubMed:34554188
	-	PROSITE-ProRule:PRU10028, PubMed:11606584, PubMed:34554188

PDB ID: 3PIX