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Ligands
Code Name Style Show Link
C9A 4-chlorobenzyl 6-fluoro-7-(4-methylpiperazin-1-yl)-1-[4-(methylsulfonyl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxylate
Non-standard Residues
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Code : 3PHE   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : HCV NS5B with a bound quinolone inhibitor
Release Data : 2010-11-17
Compound :
mol_id molecule chains
1 HCV encoded nonstructural 5B protein A,B,C,D
Source :
mol_id organism_scientific expression_system
1 Hepatitis C virus  (taxid:11103) Escherichia coli  (taxid:562)
Authors : Somoza, J.R., To, N., Lehoux, I.
Keywords : Transferase, Polymerase, RNA, Mitochondrial membrane, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Quinolones as HCV NS5B polymerase inhibitors.

Kumar, D.V.,Rai, R.,Brameld, K.A.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 82 - 87

PubMed: 21145235
DOI: 10.1016/j.bmcl.2010.11.068

Chain : A, B, C, D
UniProt : D0PY27 (D0PY27_9HEPC)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.13 ARBA:ARBA00001556
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a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.48 RuleBase:RU363062
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