Het-PDB Navi2 (PDB: 3OVE)

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Ligands
Code	Name		Style	Show	Link
CL	Chloride ion				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine
03E	1-aminocycloheptanecarboxylic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACT	Acetate ion
NH2	Amino group

Download interaction data: 3OVE

Code :

3OVE PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN/ANTAGONIST

Title :

Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide

Release Data :

2011-11-02

Compound :

mol_id	molecule	chains	synonym
1	Growth factor receptor-bound protein 2	A	Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2
	fragment: unp residues 53-163

mol_id	molecule	chains
2	PYAC7CN	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	strain: SG13009 gene: ASH, GRB2 expression_system_strain: SG13009 expression_system_vector_type: Plasmid expression_system_plasmid: pQE-60

mol_id	organism_scientific
2
	synthetic: yes

Authors :

Clements, J.H., Martin, S.F.

Keywords :

Grb2 SH2 Domain, Phosphotyrosine Binding, SIGNALING PROTEIN-ANTAGONIST complex

Exp. method :

X-RAY DIFFRACTION ( 1.82 Å )

Citation :

Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.

Myslinski, J.M.,Delorbe, J.E.,Clements, J.H. et al.
(2011) J.Am.Chem.Soc. 133 : 18518 - 18521

PDB ID: 3OVE