PDB ID: 3OTU
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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BI4 | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | PoSSuM | |||
CL | Chloride ion | PoSSuM | |||
J30 | 4-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]-4-oxobutane-1-thiol | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
Code | Name | Show |
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SEP | Phosphoserine |
Code | Name | Emphasize |
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Download interaction data: 3OTU
Structure summary
Code : | 3OTU PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE ACTIVATOR | ||||||||||||
Title : | PDK1 mutant bound to allosteric disulfide fragment activator JS30 | ||||||||||||
Release Data : | 2011-03-23 | ||||||||||||
Compound : |
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Source : |
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Authors : | Sadowsky, J.D., Wells, J.A. | ||||||||||||
Keywords : | PIF pocket, activation loop, C helix, Ser/Thr-kinase, AGC kinase, allostery, transferase, allosteric activator, bisindolylmaleimide, phosphorylation, disulfide, kinase, PDK1, TRANSFERASE-TRANSFERASE ACTIVATOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.1013 Å ) | ||||||||||||
Citation : |
Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
Sadowsky, J.D.,Burlingame, M.A.,Wolan, D.W.
et al.
PubMed: 21430264 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | O15530 (PDPK1_HUMAN) | ||||||||||||
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