Brand  (β version)

PDB ID: 3OTI

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Ligands
Code Name Style Show Link
TYD Thymidine-5'-diphosphate PoSSuM
C0T Calicheamicin t0 PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
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Modification
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Structure summary

Code : 3OTI   PDBj   RCSB PDB   PDBe
Header : transferase/antibiotic
Title : Crystal Structure of CalG3, Calicheamicin Glycostyltransferase, TDP and calicheamicin T0 bound form
Release Data : 2010-12-15
Compound :
mol_id molecule chains
1 CalG3 A,B
Source :
mol_id organism_scientific organism_common expression_system
1 Micromonospora echinospora  (taxid:1877) Micromonospora purpurea Escherichia coli  (taxid:469008)
gene: calG3
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET16b
Authors : Chang, A., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Keywords : Calicheamicin, TDP, Structural Genomics, PSI-2, Protein Structure Initiative, Center for Eukaryotic Structural Genomics, CESG, GT-B fold, Glycosyltransferase, transferase-antibiotic complex, Enzyme Discovery for Natural Product Biosynthesis, NatPro
Exp. method : X-RAY DIFFRACTION ( 1.5970 Å )
Citation :

Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.

Chang, A.,Singh, S.,Helmich, K.E.  et al.
(2011)  Proc.Natl.Acad.Sci.USA  108 : 17649 - 17654

PubMed: 21987796
DOI: 10.1073/pnas.1108484108

Reaction

Chain : A, B
UniProt : Q8KND7 (Q8KND7_MICEC)
Reaction : -