Brand  (β version)

PDB ID: 3OTH

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Ligands
Code Name Style Show Link
TYD Thymidine-5'-diphosphate PoSSuM
CLJ Calicheamicin alpha3i PoSSuM
Non-standard Residues
Code Name Show
MSE Selenomethionine
Glycosylation
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Modification
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Structure summary

Code : 3OTH   PDBj   RCSB PDB   PDBe
Header : transferase/antibiotic
Title : Crystal Structure of CalG1, Calicheamicin Glycostyltransferase, TDP and calicheamicin alpha3I bound form
Release Data : 2010-12-15
Compound :
mol_id molecule chains
1 CalG1 A,B
Source :
mol_id organism_scientific organism_common expression_system
1 Micromonospora echinospora  (taxid:1877) Micromonospora purpurea Escherichia coli  (taxid:562)
gene: calG1
expression_system_strain: B834 P(RARE2)
expression_system_vector_type: plasmid
expression_system_plasmid: pET16b
Authors : Chang, A., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Keywords : Calicheamicin, TDP, Structural Genomics, PSI-2, Protein Structure Initiative, Center for Eukaryotic Structural Genomics, CESG, GT-B fold, Glycosyltransferase, transferase-antibiotic complex, Enzyme Discovery for Natural Product Biosynthesis, NatPro
Exp. method : X-RAY DIFFRACTION ( 2.3010 Å )
Citation :

Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.

Chang, A.,Singh, S.,Helmich, K.E.  et al.
(2011)  Proc.Natl.Acad.Sci.USA  108 : 17649 - 17654

PubMed: 21987796
DOI: 10.1073/pnas.1108484108

Reaction

Chain : A, B
UniProt : Q8KNF2 (Q8KNF2_MICEC)
Reaction : -