Brand  (β version)

PDB ID: 3OP5

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Ligands
Code Name Style Show Link
REB [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile PoSSuM
EDO 1,2-ethanediol PoSSuM
GOL Glycerol PoSSuM
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Structure summary

Code : 3OP5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human vaccinia-related kinase 1
Release Data : 2010-09-22
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase VRK1 A,B,C,D Vaccinia-related kinase 1
ec: 2.7.11.1
fragment: KINASE DOMAIN, RESIDUES 3-369
mutation: K34A, K35A, E36A, E212A, K214A, E215A, E292A, K293A, K295A, K359A, K360A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: VRK1
expression_system_strain: BL21(DE3)-R3-pRARE2
expression_system_vector_type: plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Allerston, C.K., Uttarkar, S., Savitsky, P., Elkins, J.M., Filippakopoulos, P., Krojer, T., Rellos, P., Fedorov, O., Eswaran, J., Brenner, B., Keates, T., Das, S., King, O., Chalk, R., Berridge, G., von Delft, F., Gileadi, O., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : Adenosine Triphosphate, Amino Acid Sequence, Binding Sites, Catalytic Domain, Models, Molecular, Molecular Sequence Data, Phosphotransferases, Protein Conformation, Protein Folding, Surface Entropy Reduction, Structural Genomics, Structural Genomics Consortium, SGC, transferase
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.

Counago, R.M.,Allerston, C.K.,Savitsky, P.  et al.
(2017)  Sci Rep  7 : 7501 - 7501

PubMed: 28790404
DOI: 10.1038/s41598-017-07755-y

Reaction

Chain : A, B, C, D
UniProt : Q99986 (VRK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:21543316
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:21543316
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