Het-PDB Navi2 (PDB: 3O5X)

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Ligands
Code	Name		Style	Show	Link
JZG	3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1h-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid				PoSSuM

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Download interaction data: 3O5X

Code :

3O5X PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor

Release Data :

2010-08-11

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein phosphatase non-receptor type 11	A	Protein-tyrosine phosphatase 2C, PTP-2C, Protein-tyrosine phosphatase 1D, PTP-1D, SH-PTP3, SH-PTP2, SHP-2, Shp2
	ec: 3.1.3.48 fragment: UNP RESIDUES 262-532, CATALYTIC DOMAIN

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

Authors :

Zhang, Z.-Y., Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z., Yang, Z., Dong, Y., Nabinger, S.C., Wu, L., Gunawan, A.M., Wang, L., Chan, R.J.

Keywords :

SHP2-IIB-08 complex, inhibitor, binding affinity, binding selectivity, receptor, Hydrolase, Dephosphorylation

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).

Zhang, X.,He, Y.,Liu, S. et al.
(2010) J.Med.Chem. 53 : 2482 - 2493

Chain :

UniProt :

Q06124 (PTN11_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044, PubMed:20170098, PubMed:26742426, PubMed:28074573
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PDB ID: 3O5X