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Ligands
Code Name Style Show Link
ARS Arsenic
GOL Glycerol
MG Magnesium ion
ZG1 1-ethyl-5-[3-(2-oxo-2-pyrrolidin-1-ylethyl)-1,2,4-oxadiazol-5-yl]-N-(tetrahydro-2h-pyran-4-yl)-1h-pyrazolo[3,4-B]pyridin-4-amine
ZN Zinc ion
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Code : 3O56   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor
Release Data : 2011-08-03
Compound :
mol_id molecule chains synonym
1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B A DPDE4, PDE32
ec: 3.1.4.17
fragment: Catalytic domain, UNP residues 324-675
mutation: S482A, S487A, S489A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PDE4B, DPDE4
expression_system_common: Fall armyworm
expression_system_vector_type: Baculovirus
Authors : Somers, D.O., Neu, M.
Keywords : PDE, HYDROLASE, PHOSPHODIESTERASE, cAMP Binding, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.4200 Å )
Citation :

Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SAR.

Mitchell, C.J.,Ballantine, S.P.,Coe, D.M.  et al.
(2010)  Bioorg.Med.Chem.Lett.  20 : 5803 - 5806

PubMed: 20732811
DOI: 10.1016/j.bmcl.2010.07.136

Chain : A
UniProt : Q07343 (PDE4B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
3',5'-cyclic AMP + H2O = AMP + H(+) 3.1.4.53 PubMed:15260978, PubMed:17519386, PubMed:8392015, PubMed:9371714
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