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Ligands
Code Name Style Show Link
CLR Cholesterol
JRZ (2s,3s)-1-[(7-methyl-2,3-dihydro-1h-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol
OLA Oleic acid
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate
PGE Triethylene glycol
Non-standard Residues
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Code : 3NY8   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551
Release Data : 2010-08-11
Compound :
mol_id molecule chains synonym
1 Beta-2 adrenergic receptor, Lysozyme A BETA-2 ADRENORECEPTOR, BETA-2 ADRENOCEPTOR, LYSIS PROTEIN, MURAMIDASE, ENDOLYSIN
fragment: Chimeric protein of Beta-2 Adrenoreceptor 1-230, Lysozyme 2-161, Beta-2 adrenergic receptor 263-348
mutation: E122W, N187E, C1054T, C1097A
Source :
mol_id organism_scientific expression_system
1 Enterobacteria phage T4  (taxid:10665) Spodoptera frugiperda  (taxid:7108)
gene: ADRB2, ADRB2R, B2AR, E
expression_system_common: Fall armyworm
expression_system_strain: Sf9
expression_system_vector_type: Baculovirus
expression_system_plasmid: PFASTBAC
Authors : Wacker, D., Fenalti, G., Brown, M.A., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Keywords : G Protein-coupled receptor, Lysozyme, Fusion, Transducer, Adrenergic, G-Proteins, Arrestins, Adrenalin, ICI 118, 551, Glycosylation, Palmitoylation, Phosphorylation, Membrane Protein, HYDROLASE, Structural Genomics, PSI-2, Protein Structure Initiative, Accelerated Technologies Center for Gene to 3D Structure, ATCG3D, GPCR Network, GPCR
Exp. method : X-RAY DIFFRACTION ( 2.84 Å )
Citation :

Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

Wacker, D.,Fenalti, G.,Brown, M.A.  et al.
(2010)  J.Am.Chem.Soc.  132 : 11443 - 11445

PubMed: 20669948
DOI: 10.1021/ja105108q

Chain : A
UniProt : P07550 (ADRB2_HUMAN)
Reaction : -
Chain : A
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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