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Ligands
Code Name Style Show Link
GOL Glycerol
SO4 Sulfate ion
JOZ 3,4-dihydroisoquinolin-1(2h)-one
Non-standard Residues
Code Name Show
SEP Phosphoserine
Glycosylation
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Code : 3NUU   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : phosphoinositide-dependent kinase-1 (PDK1) with fragment11
Release Data : 2011-05-25
Compound :
mol_id molecule chains
1 PkB-like A
fragment: UNP residues 65-350
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Baculovirus  (taxid:10469)
gene: PkB-like 1
Authors : Campobasso, N., Ward, P.
Keywords : Kinase domain, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.9803 Å )
Citation :

Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery.

Medina, J.R.,Blackledge, C.W.,Heerding, D.A.  et al.
(2010)  ACS Med Chem Lett  1 : 439 - 442

PubMed: 24900229
DOI: 10.1021/ml100136n

Chain : A
UniProt : Q9UPJ8 (Q9UPJ8_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 ARBA:ARBA00001433
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 ARBA:ARBA00000775
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