Brand  (β version)

PDB ID: 3NNT

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Ligands
Code Name Style Show Link
DQA 1,3,4-trihydroxy-5-oxo-cyclohexanecarboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3NNT   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal Structure of K170M Mutant of Type I 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 in Non-Covalent Complex with Dehydroquinate.
Release Data : 2010-07-28
Compound :
mol_id molecule chains synonym
1 3-dehydroquinate dehydratase A,B 3-dehydroquinase, Type I DHQase
ec: 4.2.1.10
mutation: K170M
Source :
mol_id organism_scientific expression_system
1 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:99287) Escherichia coli  (taxid:469008)
strain: LT2
gene: aroD, STM1358
expression_system_strain: BL21-DE3
expression_system_vector_type: plasmid
expression_system_plasmid: pMCSG7
Authors : Minasov, G., Light, S.H., Shuvalova, L., Papazisi, L., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Keywords : Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates.

Light, S.H.,Minasov, G.,Shuvalova, L.  et al.
(2011)  J.Biol.Chem.  286 : 3531 - 3539

PubMed: 21087925
DOI: 10.1074/jbc.M110.192831

Reaction

Chain : A, B
UniProt : P58687 (AROD_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
3-dehydroquinate = 3-dehydroshikimate + H2O 4.2.1.10 HAMAP- Rule:MF_00214, PubMed:21087925, PubMed:21291284, PubMed:23341204, PubMed:24957267
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