Het-PDB Navi2 (PDB: 3NF7)

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Ligands
Code	Name	Link
ACY	Acetic acid	PoSSuM
CIW	5-[(5-chloro-2-oxo-2,3-dihydro-1h-indol-1-yl)methyl]-1,3-benzodioxole-4-carboxylic acid	PoSSuM
EDO	1,2-ethanediol	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
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Download interaction data: 3NF7

Code :

3NF7 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design

Release Data :

2011-04-27

Compound :

mol_id	molecule	chains
1	Integrase	A,B
	fragment: catalytic domain, UNP residues 50-212 mutation: F185H, C56S, F139D

Source :

mol_id	organism_scientific	expression_system
1	Human immunodeficiency virus 1 (taxid:11676)	Escherichia coli (taxid:562)

Authors :

Peat, T.S., Newman, J., Deadman, J.J., Rhodes, D.

Keywords :

INTEGRASE, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.80 Å )

Citation :

Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

Rhodes, D.I.,Peat, T.S.,Vandegraaff, N. et al.
(2011) ANTIVIR.CHEM.CHEMOTHER. 21 : 155 - 168

PDB ID: 3NF7