Brand  (β version)

PDB ID: 3MY1

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
PO4 Phosphate ion PoSSuM
RFZ 5,6-dichloro-1-beta-D-ribofuranosyl-1h-benzimidazole PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 3MY1   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/PROTEIN BINDING/INHIBITOR
Title : Structure of CDK9/cyclinT1 in complex with DRB
Release Data : 2010-09-29
Compound :
mol_id molecule chains synonym
1 Cell division protein kinase 9 A Cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, Cell division cycle 2-like protein kinase 4, C-2K
ec: 2.7.11.22, 2.7.11.23
fragment: UNP residues 2-330
mol_id molecule chains synonym
2 Cyclin-T1 B Cyclin-T, CycT1
fragment: UNP residues 2-259
mutation: Q77R, E96G, F241L
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDC2L4, CDK9
expression_system_strain: SF9
expression_system_vector_type: BACULO VIRUS
expression_system_plasmid: PVL1392
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CCNT1
expression_system_strain: SF9
expression_system_vector_type: BACULO VIRUS
expression_system_plasmid: PVL1392
Authors : Baumli, S., Johnson, L.N.
Keywords : CDK-cyclin complex, phosphorylated, TRANSCRIPTION-PROTEIN BINDING-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.800 Å )
Citation :

Halogen bonds form the basis for selective P-TEFb inhibition by DRB

Baumli, S.,Endicott, J.A.,Johnson, L.N.
(2010)  Chem.Biol.  17 : 931 - 936

PubMed: 20851342
DOI: 10.1016/j.chembiol.2010.07.012

Reaction

Chain : A
UniProt : P50750 (CDK9_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:12037670, PubMed:20980437, PubMed:29335245
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:12037670, PubMed:20980437
left-to-right PubMed:12037670, PubMed:20980437
[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase] 2.7.11.23 PubMed:21127351, PubMed:28426094
left-to-right
Chain : B
UniProt : O60563 (CCNT1_HUMAN)
Reaction : -