Brand  (β version)

PDB ID: 3MXF

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
IOD Iodide ion PoSSuM
JQ1 (6s)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3MXF   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JQ1
Release Data : 2010-10-06
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A Protein HUNK1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: BRD4, HUNK1, Mcap
expression_system_strain: BL21(DE3)-R3
expression_system_vector_type: Plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Filippakopoulos, P., Picaud, S., Qi, J., Keates, T., Felletar, I., Fedorov, O., Muniz, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bradner, J.E., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : Bromodomain-containing protein 4 isoform long, BRD4, Bromodomain containing protein 4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, JQ1, betsoff1, Structural Genomics Consortium, SGC, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 1.600 Å )
Citation :

Selective inhibition of BET bromodomains.

Filippakopoulos, P.,Qi, J.,Picaud, S.  et al.
(2010)  Nature  468 : 1067 - 1073

PubMed: 20871596
DOI: 10.1038/nature09504

Reaction

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -