PDB ID: 3ME6
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Structure summary
Code : | 3ME6 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel | ||||||||||||
Release Data : | 2010-09-15 | ||||||||||||
Compound : |
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Source : |
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Authors : | Gay, S.C., Roberts, A.G., Maekawa, K., Talakad, J.C., Hong, W.X., Zhang, Q., Stout, C.D., Halpert, J.R. | ||||||||||||
Keywords : | P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4, CYP LM2 | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 3.100 Å ) | ||||||||||||
Citation : |
Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.
Gay, S.C.,Roberts, A.G.,Maekawa, K.
et al.
PubMed: 20815363 Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
Zhao, Y.,White, M.A.,Muralidhara, B.K.
et al.
PubMed: 16373351 Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9 {angstrom} resolution: Insight into the range of P450 conformations and coordination of redox partner binding.
Scott, E.E.,White, M.A.,He, Y.A.
et al.
PubMed: 15100217 An open conformation of mammalian cytochrome P450 2B4 at 1.6 A resolution.
Scott, E.E.,He, Y.A.,Wester, M.R.
et al.
PubMed: 14563924 Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Zhao, Y.,Sun, L.,Muralidhara, B.K.
et al.
PubMed: 17887776 Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1H-imidazole: Ligand-Induced Structural Response through Alpha-Helical Repositioning
Gay, S.C.,Sun, L.,Maekawa, K.
et al.
PubMed: 19397311 |
Reaction
Chain : | A, B, C, D | ||||||||
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UniProt : | P00178 (CP2B4_RABIT) | ||||||||
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