Het-PDB Navi2 (PDB: 3ME6)

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Ligands
Code	Name		Style	Show	Link
HEM	Protoporphyrin ix containing Fe				PoSSuM
CGE	Clopidogrel				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3ME6

Code :

3ME6 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel

Release Data :

2010-09-15

Compound :

mol_id	molecule	chains	synonym
1	Cytochrome P450 2B4	A,B,C,D	CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1
	ec: 1.14.14.1 mutation: E2A, G22K, H23K, P24T, K25S, A26S, H27K, R29K, H226Y

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Oryctolagus cuniculus (taxid:9986)	Rabbit	Escherichia coli (taxid:562)
	gene: CYP2B4 expression_system_strain: TOPP3 expression_system_vector_type: plasmid expression_system_plasmid: PKK

Authors :

Gay, S.C., Roberts, A.G., Maekawa, K., Talakad, J.C., Hong, W.X., Zhang, Q., Stout, C.D., Halpert, J.R.

Keywords :

P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4, CYP LM2

Exp. method :

X-RAY DIFFRACTION ( 3.100 Å )

Citation :

Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.

Gay, S.C.,Roberts, A.G.,Maekawa, K. et al.
(2010) Biochemistry 49 : 8709 - 8720

PubMed: 20815363
DOI: 10.1021/bi100914z

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

Zhao, Y.,White, M.A.,Muralidhara, B.K. et al.
(2006) J.Biol.Chem. 281 : 5973 - 5981

PubMed: 16373351
DOI: 10.1074/jbc.M511464200

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9 {angstrom} resolution: Insight into the range of P450 conformations and coordination of redox partner binding.

Scott, E.E.,White, M.A.,He, Y.A. et al.
(2004) J.Biol.Chem. 279 : 27294 - 27301

PubMed: 15100217
DOI: 10.1074/jbc.M403349200

An open conformation of mammalian cytochrome P450 2B4 at 1.6 A resolution.

Scott, E.E.,He, Y.A.,Wester, M.R. et al.
(2003) Proc.Natl.Acad.Sci.USA 100 : 13196 - 13201

PubMed: 14563924
DOI: 10.1073/pnas.2133986100

Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.

Zhao, Y.,Sun, L.,Muralidhara, B.K. et al.
(2007) Biochemistry 46 : 11559 - 11567

PubMed: 17887776
DOI: 10.1021/bi7011614

Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1H-imidazole: Ligand-Induced Structural Response through Alpha-Helical Repositioning

Gay, S.C.,Sun, L.,Maekawa, K. et al.
(2009) Biochemistry 48 : 4762 - 4771

PubMed: 19397311
DOI: 10.1021/bi9003765

Chain :

A, B, C, D

UniProt :

P00178 (CP2B4_RABIT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]	1.14.14.1	-
	-	-

PDB ID: 3ME6

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