Het-PDB Navi2 (PDB: 3MA3)

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Ligands
Code	Name		Style	Show	Link
01I	Naphtho[2,1-B:7,6-B']difuran-2,8-dicarboxylic acid				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine

Glycosylation
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Download interaction data: 3MA3

Code :

3MA3 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand

Release Data :

2010-04-14

Compound :

mol_id	molecule	chains
1	Proto-oncogene serine/threonine-protein kinase pim-1	A
	ec: 2.7.11.1 fragment: UNP residues 92-403

mol_id	molecule	chains	synonym
2	Pimtide	B	consensus PIM1 substrate peptide

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: PIM1 expression_system_strain: BL21(DE3)-R3 expression_system_vector_type: Plasmid expression_system_plasmid: pNIC28-Bsa4

mol_id	organism_scientific
2
	synthetic: yes

Authors :

Filippakopoulos, P., Bullock, A., Fedorov, O., Vollmar, M., von Delft, F., Cochet, C., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Keywords :

ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE, Cell cycle, Cell membrane

Exp. method :

X-RAY DIFFRACTION ( 2.300 Å )

Citation :

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

Lopez-Ramos, M.,Prudent, R.,Moucadel, V. et al.
(2010) Faseb J. 24 : 3171 - 3185

PubMed: 20400536
DOI: 10.1096/fj.09-143743

Chain :

UniProt :

P11309 (PIM1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394
	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862
	-	PubMed:15525646, PubMed:15657054, PubMed:15808862

PDB ID: 3MA3

Hetero Atom Contents

Structure summary

Reaction