Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
MG Magnesium ion
ZN Zinc ion
C7P Cis-diammine(pyridine)chloroplatinum(II)
Code : 3M4O
Header : TRANSFERASE/DNA-RNA HYBRID
Title : RNA polymerase II elongation complex B
Release Data : 2010-05-12
Compound :
mol_id molecule chains synonym
1 DNA-directed RNA polymerase II subunit RPB1 A RNA polymerase II subunit B1, RNA polymerase II subunit 1, DNA-directed RNA polymerase III largest subunit, RNA polymerase II subunit B220
ec: 2.7.7.6
mol_id molecule chains synonym
2 DNA-directed RNA polymerase II subunit RPB2 B RNA polymerase II subunit 2, DNA-directed RNA polymerase II 140 kDa polypeptide, B150
ec: 2.7.7.6
mol_id molecule chains synonym
3 DNA-directed RNA polymerase II subunit RPB3 C RNA polymerase II subunit B3, RNA polymerase II subunit 3, DNA-directed RNA polymerase II 45 kDa polypeptide, B44.5
mol_id molecule chains synonym
4 DNA-directed RNA polymerases I, II, and III subunit RPABC1 E RNA polymerases I, II, and III subunit ABC1, DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide, ABC27
mol_id molecule chains synonym
5 DNA-directed RNA polymerases I, II, and III subunit RPABC2 F RNA polymerases I, II, and III subunit ABC2, DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide, ABC23
mol_id molecule chains synonym
6 DNA-directed RNA polymerases I, II, and III subunit RPABC3 H RNA polymerases I, II, and III subunit ABC3, DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide, ABC14.5, ABC14.4
mol_id molecule chains synonym
7 DNA-directed RNA polymerase II subunit RPB9 I RNA polymerase II subunit B9, DNA-directed RNA polymerase II subunit 9, DNA-directed RNA polymerase II 14.2 kDa polypeptide, B12.6
mol_id molecule chains synonym
8 DNA-directed RNA polymerases I, II, and III subunit RPABC5 J RNA polymerases I, II, and III subunit ABC5, DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide, ABC10-beta, ABC8
mol_id molecule chains synonym
9 DNA-directed RNA polymerase II subunit RPB11 K RNA polymerase II subunit B11, DNA-directed RNA polymerase II 13.6 kDa polypeptide, B13.6
mol_id molecule chains synonym
10 DNA-directed RNA polymerases I, II, and III subunit RPABC4 L RNA polymerases I, II, and III subunit ABC4, ABC10-alpha
mol_id molecule chains
11 RNA (5'-R(*AP*UP*GP*GP*AP*GP*AP*GP*GP*A)-3') R
mol_id molecule chains
12 DNA (28-MER) T
mol_id molecule chains
13 DNA (5'-D(P*GP*TP*GP*GP*TP*TP*AP*TP*GP*GP*GP*TP*AP*G)-3') N
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast,lager beer yeast,yeast
mol_id organism_scientific
11
synthetic: yes
mol_id organism_scientific
12
synthetic: yes
mol_id organism_scientific
13
synthetic: yes
Authors : Wang, D., Zhu, G., Huang, X., Lippard, S.J.
Keywords : TRANSCRIPTION, MRNA, MULTIPROTEIN COMPLEX, MOLECULAR MACHINE, DNA, DNA Damage, Cancer, Platinum Drug, DNA-binding, DNA-directed RNA polymerase, Isopeptide bond, Magnesium, Metal-binding, Nucleotidyltransferase, Nucleus, Phosphoprotein, Transferase, Ubl conjugation, Zinc, Zinc-finger, Polymorphism, Cytoplasm, DNA repair, TRANSFERASE-DNA-RNA HYBRID complex
Exp. method : X-RAY DIFFRACTION ( 3.57 Å )
Citation :

X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.

Wang, D.,Zhu, G.,Huang, X.  et al.
(2010)  Proc.Natl.Acad.Sci.USA  107 : 9584 - 9589

PubMed: 20448203
DOI: 10.1073/pnas.1002565107

Chain : A
UniProt : P04050 (RPB1_YEAST)
Reaction : Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Chain : B
UniProt : P08518 (RPB2_YEAST)
Reaction : Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Chain : C
UniProt : P16370 (RPB3_YEAST)
Reaction : -
Chain : E
UniProt : P20434 (RPAB1_YEAST)
Reaction : -
Chain : F
UniProt : P20435 (RPAB2_YEAST)
Reaction : -
Chain : H
UniProt : P20436 (RPAB3_YEAST)
Reaction : -
Chain : I
UniProt : P27999 (RPB9_YEAST)
Reaction : -
Chain : J
UniProt : P22139 (RPAB5_YEAST)
Reaction : -
Chain : K
UniProt : P38902 (RPB11_YEAST)
Reaction : -
Chain : L
UniProt : P40422 (RPAB4_YEAST)
Reaction : -