Brand  (β version)

PDB ID: 3LTH

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Ligands
Code Name Style Show Link
FFQ [(1r)-1-hydroxypropyl]phosphonic acid PoSSuM
UD1 Uridine-diphosphate-N-acetylglucosamine PoSSuM
Non-standard Residues
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IAS Beta-L-aspartic acid
Glycosylation
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Structure summary

Code : 3LTH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/ANTIBIOTIC
Title : E. cloacae MurA dead-end complex with UNAG and fosfomycin
Release Data : 2010-05-05
Compound :
mol_id molecule chains synonym
1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase A Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT
ec: 2.5.1.7
Source :
mol_id organism_scientific expression_system
1 Enterobacter cloacae  (taxid:550) Escherichia coli  (taxid:562)
gene: murA, murZ
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pET9d
Authors : Schonbrunn, E.
Keywords : open enzyme state, inside-out alpha/beta barrel, Cell wall biogenesis/degradation, Peptidoglycan synthesis, Transferase, TRANSFERASE-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .

Han, H.,Yang, Y.,Olesen, S.H.  et al.
(2010)  Biochemistry  49 : 4276 - 4282

PubMed: 20392080
DOI: 10.1021/bi100365b

Reaction

Chain : A
UniProt : P33038 (MURA_ENTCC)
Reaction: EC: Evidence:
Physiological Direction:
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine 2.5.1.7 HAMAP-Rule:MF_00111, PubMed:20392080, PubMed:22378791
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