Brand  (β version)

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centroid:
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Ligands
Code Name Link
FB4 2-(2-amino-4-chlorophenoxy)-5-chlorophenol
NAD Nicotinamide-adenine-dinucleotide
Code : 3LT4
Header : OXIDOREDUCTASE
Title : Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4
Release Data : 2010-06-16
Compound :
mol_id molecule chains
1 Enoyl-ACP reductase A,B
ec: 1.3.1.9
fragment: residues 96-424
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum  (taxid:5833) Escherichia coli  (taxid:562)
gene: fabI
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-28a(+)(NOVAGEN)
Authors : Maity, K., Bhargav, S.P., Surolia, N., Surolia, A., Suguna, K.
Keywords : Triclosan, Triclosan variant, Enoyl-ACP reductase, oxidoreductase, P.falciparum
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition

Maity, K.,Bhargav, S.P.,Sankaran, B.  et al.
(2010)  Iubmb Life  62 : 467 - 476

PubMed: 20503440
DOI: 10.1002/iub.327

Chain : A, B
UniProt : Q9BJJ9 (No found in current UniProtKB/SwissProt)
Reaction : -