Het-PDB Navi2 (PDB: 3LPU)

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Ligands
Code	Name	Link
976	(2s)-2-(6-chloro-2-methyl-4-phenylquinolin-3-yl)pentanoic acid	PoSSuM
CA	Calcium ion	PoSSuM
P03	2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol	PoSSuM
PEG	Di(hydroxyethyl)ether	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
Code	Name	Show
CAF	S-dimethylarsinoyl-cysteine

Glycosylation
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Modification
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Download interaction data: 3LPU

Code :

3LPU PDBj RCSB PDB PDBe

Header :

VIRAL PROTEIN

Title :

HIV integrase

Release Data :

2010-05-12

Compound :

mol_id	molecule	chains
1	Integrase	A
	fragment: HIV integrase core domain mutation: F185K

Source :

mol_id	organism_scientific	expression_system
1	Human immunodeficiency virus 1 (taxid:11676)	Escherichia coli (taxid:562)

Authors :

Nicolet, S., Christ, F., Voet, A., Marchand, A., Strelkov, S.V., de Maeyer, M., Chaltin, P., Debyzer, Z.

Keywords :

HIV, integrase, LEDGF/p75 small molecule, inhibitor, Endonuclease, Hydrolase, Nuclease, Transferase, VIRAL PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.95 Å )

Citation :

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.

Christ, F.,Voet, A.,Marchand, A. et al.
(2010) Nat.Chem.Biol. 6 : 442 - 448

PDB ID: 3LPU