Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FMY N-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)aniline
Modified Residues
Code Name Link
OCY Hydroxyethylcysteine
Code : 3KVX
Header : TRANSFERASE
Title : JNK3 bound to aminopyrimidine inhibitor, SR-3562
Release Data : 2009-12-22
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 10 A Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
ec: 2.7.11.24
fragment: residues 39-402
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK10, JNK3, JNK3A, PRKM10
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pDEST14
Authors : Habel, J.E., Laughlin, J.D., LoGrasso, P.
Keywords : JNK3, MAPK10, inhibitor, ATP-binding, Epilepsy, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Kamenecka, T.,Jiang, R.,Song, X.  et al.
(2010)  J.Med.Chem.  53 : 419 - 431

PubMed: 19947601
DOI: 10.1021/jm901351f

Chain : A
UniProt : P53779 (MK10_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.