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Ligands
Code Name Style Show Link
951 2-[(2e)-2-{[5-(2-chlorophenyl)furan-2-yl]methylidene}hydrazino]benzoic acid
ACT Acetate ion
DET Undecylamine-N,N-dimethyl-N-oxide
DOR (4s)-2,6-dioxohexahydropyrimidine-4-carboxylic acid
FMN Flavin mononucleotide
SO4 Sulfate ion
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Code : 3KVM   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution
Release Data : 2010-03-02
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase, mitochondrial A DHOdehase, Dihydroorotate oxidase
ec: 1.3.5.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DHODH
expression_system_strain: BL21(DE3)PYRD
expression_system_vector_type: Plasmid
expression_system_plasmid: PET19B
Authors : McLean, L., Zhang, Y.
Keywords : PROTEIN-ANTIPROLIFERATIVE AGENT COMPLEX, OXIDOREDUCTASE, Flavoprotein, FMN, Membrane, Mitochondrion, Mitochondrion inner membrane, Polymorphism, Pyrimidine biosynthesis, Transit peptide, Transmembrane
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures.

McLean, L.R.,Zhang, Y.,Degnen, W.  et al.
(2010)  Bioorg.Med.Chem.Lett.  20 : 1981 - 1984

PubMed: 20153645
DOI: 10.1016/j.bmcl.2010.01.115

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = a quinol + orotate 1.3.5.2 PubMed:8925840
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