PDB ID: 3KVM
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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951 | 2-[(2e)-2-{[5-(2-chlorophenyl)furan-2-yl]methylidene}hydrazino]benzoic acid | PoSSuM | |||
ACT | Acetate ion | PoSSuM | |||
DET | Undecylamine-N,N-dimethyl-N-oxide | PoSSuM | |||
DOR | (4s)-2,6-dioxohexahydropyrimidine-4-carboxylic acid | PoSSuM | |||
FMN | Flavin mononucleotide | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 3KVM
Structure summary
Code : | 3KVM PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution | ||||||||||||
Release Data : | 2010-03-02 | ||||||||||||
Compound : |
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Source : |
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Authors : | McLean, L., Zhang, Y. | ||||||||||||
Keywords : | PROTEIN-ANTIPROLIFERATIVE AGENT COMPLEX, OXIDOREDUCTASE, Flavoprotein, FMN, Membrane, Mitochondrion, Mitochondrion inner membrane, Polymorphism, Pyrimidine biosynthesis, Transit peptide, Transmembrane | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.000 Å ) | ||||||||||||
Citation : |
Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures.
McLean, L.R.,Zhang, Y.,Degnen, W.
et al.
PubMed: 20153645 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q02127 (PYRD_HUMAN) | ||||||||
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