Brand  (β version)

PDB ID: 3KCX

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Ligands
Code Name Style Show Link
CQL 5-chloro-7-iodoquinolin-8-ol PoSSuM
FE2 Fe (II) ion PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3KCX   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Factor inhibiting HIF-1 alpha in complex with Clioquinol
Release Data : 2010-04-28
Compound :
mol_id molecule chains synonym
1 Hypoxia-inducible factor 1-alpha inhibitor A Hypoxia-inducible factor asparagine hydroxylase, Factor inhibiting HIF-1, FIH-1
ec: 1.14.11.16
fragment: residues 15-349
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Moon, H., Han, S., Choe, J.
Keywords : hypoxia, HIF-1, FIH-1, inhibitor, Dioxygenase, Iron, Metal-binding, Nucleus, Oxidoreductase, Transcription, Transcription regulation
Exp. method : X-RAY DIFFRACTION ( 2.600 Å )
Citation :

Crystal structures of human FIH-1 in complex with quinol family inhibitors

Moon, H.,Han, S.,Park, H.  et al.
(2010)  Mol.Cells  29 : 471 - 474

PubMed: 20396966
DOI: 10.1007/s10059-010-0058-3

Reaction

Chain : A
UniProt : Q9NWT6 (HIF1N_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate 1.14.11.30 PubMed:12042299, PubMed:12080085, PubMed:14701857, PubMed:17573339
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2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate 1.14.11.n4 PubMed:21251231
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2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate 1.14.11.n4 PubMed:17003112, PubMed:17573339, PubMed:18299578, PubMed:19245366, PubMed:21177872
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2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate 1.14.11.n4 PubMed:21177872
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