PDB ID: 3KB7
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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071 | 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1h-pyrazolo[4,3-H]quinazoline-3-carboxamide | PoSSuM | |||
TLA | L(+)-tartaric acid | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
Code | Name | Show |
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NMM | (2s)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid |
Code | Name | Emphasize |
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Code | Name | Show |
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Download interaction data: 3KB7
Structure summary
Code : | 3KB7 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor | ||||||||||||
Release Data : | 2010-05-19 | ||||||||||||
Compound : |
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Source : |
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Authors : | Bossi, R.T., Bertrand, J.A. | ||||||||||||
Keywords : | PROTEIN KINASE, ATP-binding, Cell cycle, Cell division, Kinase, Mitosis, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.500 Å ) | ||||||||||||
Citation : |
Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors
Beria, I.,Ballinari, D.,Bertrand, J.A.
et al.
PubMed: 20397705 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P53350 (PLK1_HUMAN) | ||||||||||||
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