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Ligands
Code Name Style Show Link
071 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1h-pyrazolo[4,3-H]quinazoline-3-carboxamide
TLA L(+)-tartaric acid
ZN Zinc ion
Non-standard Residues
Code Name Show
NMM (2s)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid
Glycosylation
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Modification
Code Name Show
Code : 3KB7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor
Release Data : 2010-05-19
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase PLK1 A Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13
ec: 2.7.11.21
fragment: kinase domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PLK1
expression_system_common: Fall armyworm
expression_system_cell_line: H5
expression_system_vector_type: baculovirus
Authors : Bossi, R.T., Bertrand, J.A.
Keywords : PROTEIN KINASE, ATP-binding, Cell cycle, Cell division, Kinase, Mitosis, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.500 Å )
Citation :

Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors

Beria, I.,Ballinari, D.,Bertrand, J.A.  et al.
(2010)  J.Med.Chem.  53 : 3532 - 3551

PubMed: 20397705
DOI: 10.1021/jm901713n

Chain : A
UniProt : P53350 (PLK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.21 PubMed:11202906, PubMed:12207013, PubMed:21880710, PubMed:22325354, PubMed:37440612, PubMed:37674080
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.21 PubMed:11202906, PubMed:12207013, PubMed:21880710, PubMed:37674080
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