Brand  (β version)

PDB ID: 3K3J

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Ligands
Code Name Style Show Link
F4C 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide PoSSuM
I46 2-fluoro-4-[4-(4-fluorophenyl)-1h-pyrazol-3-yl]pyridine PoSSuM
Non-standard Residues
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Structure summary

Code : 3K3J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : P38alpha bound to novel DFG-out compound PF-00416121
Release Data : 2009-11-10
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2
Authors : Kazmirski, S.L., DiNitto, J.P.
Keywords : p38alpha kinase, ATP-binding, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.995 Å )
Citation :

The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay.

Tecle, H.,Feru, F.,Liu, H.  et al.
(2009)  Chem.Biol.Drug Des.  74 : 547 - 559

PubMed: 19843080
DOI: 10.1111/j.1747-0285.2009.00884.x

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:10838079
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