PDB ID: 3K22
Hetero Atom Contents
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JZS | N-[(1r)-2-amino-1-methyl-2-oxoethyl]-3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]amino}-1h-indazol-1-yl)benzamide | PoSSuM | |||
JZR | Hexyl beta-D-glucopyranoside | PoSSuM |
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Download interaction data: 3K22
Structure summary
Code : | 3K22 PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSCRIPTION | ||||||||||||||||||||||||
Title : | Glucocorticoid Receptor with Bound alaninamide 10 with TIF2 peptide | ||||||||||||||||||||||||
Release Data : | 2010-08-11 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Biggadike, K.B., McLay, I.M., Madauss, K.P., Williams, S.P., Bledsoe, R.K. | ||||||||||||||||||||||||
Keywords : | Glucocorticoid Receptor, Steroid Hormone Receptor, Nuclear Receptor, GR, glucocorticoids, alpha helical sandwich, meta-channel, Alternative initiation, Chromatin regulator, Disease mutation, DNA-binding, Isopeptide bond, Lipid-binding, Metal-binding, Nucleus, Phosphoprotein, Pseudohermaphroditism, Receptor, Steroid-binding, Transcription, Transcription regulation, Zinc-finger | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.100 Å ) | ||||||||||||||||||||||||
Citation : |
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Biggadike, K.,Bledsoe, R.K.,Coe, D.M.
et al.
PubMed: 19822747 |
Reaction
Chain : | A, B |
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UniProt : | P04150 (GCR_HUMAN) |
Reaction : | - |