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Ligands
Code Name Style Show Link
JZH (3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-Cd]inden-4(3h)-one
NA Sodium ion
Non-standard Residues
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PTR O-phosphotyrosine
Glycosylation
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Code : 3JY9   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Janus Kinase 2 Inhibitors
Release Data : 2009-12-01
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK2 A Janus kinase 2, JAK-2
ec: 2.7.10.2
fragment: UNP residue 842-1130, Protein kinase 2 domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Baculovirus  (taxid:10469)
gene: JAK2
expression_system_strain: Sf9
expression_system_vector_type: plasmid
expression_system_plasmid: pBEV1
Authors : Zuccola, H.J., Ledeboer, M.W., Pierce, A.C.
Keywords : kinase, inhibitor, jak2, janus kinase, ATP-binding, Disease mutation, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, Transferase, Tyrosine-protein kinase
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.

Wang, T.,Duffy, J.P.,Wang, J.  et al.
(2009)  J.Med.Chem.  52 : 7938 - 7941

PubMed: 20014869
DOI: 10.1021/jm901383u

Chain : A
UniProt : O60674 (JAK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:7615558, PubMed:9618263
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