Brand  (β version)

PDB ID: 3JWE

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Ligands
Code Name Style Show Link
F4P 1-[bis(4-fluorophenyl)methyl]-4-(1h-1,2,4-triazol-1-ylcarbonyl)piperazine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3JWE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of human mono-glyceride lipase in complex with SAR629
Release Data : 2010-01-26
Compound :
mol_id molecule chains synonym
1 MGLL protein A,B Monoglyceride lipase, isoform CRA_b, cDNA, FLJ96595, Homo sapiens monoglyceride lipase (MGLL), mRNA
ec: 3.1.1.23
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human ESCHERICHIA COLI  (taxid:562)
gene: MGLL, hCG_40840
Authors : Bertrand, T., Auge, F., Houtmann, J., Rak, A., Vallee, F., Mikol, V., Berne, P.F., Michot, N., Cheuret, D., Hoornaert, C., Mathieu, M.
Keywords : alpha-beta hydrolase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Structural basis for human monoglyceride lipase inhibition.

Bertrand, T.,Auge, F.,Houtmann, J.  et al.
(2010)  J.Mol.Biol.  396 : 663 - 673

PubMed: 19962385
DOI: 10.1016/j.jmb.2009.11.060

Reaction

Chain : A, B
UniProt : Q6IBG9 (MGLL_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolyzes glycerol monoesters of long-chain fatty acids. 3.1.1.23 PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842
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1-octanoylglycerol + H2O = glycerol + H(+) + octanoate - PubMed:22969151, PubMed:24368842
left-to-right
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) - PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842
left-to-right
1-decanoylglycerol + H2O = decanoate + glycerol + H(+) - PubMed:22969151, PubMed:24368842
left-to-right
1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+) - PubMed:22969151, PubMed:24368842
left-to-right
1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate - PubMed:22969151, PubMed:24368842
left-to-right PubMed:22969151, PubMed:24368842
2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate - PubMed:22969151, PubMed:24368842
left-to-right PubMed:22969151, PubMed:24368842
1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+) - PubMed:20079333, PubMed:22969151, PubMed:24368842
left-to-right PubMed:20079333, PubMed:22969151, PubMed:24368842
2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+) - PubMed:22969151, PubMed:24368842
left-to-right PubMed:22969151, PubMed:24368842
2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+) - PubMed:22969151, PubMed:24368842
left-to-right
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) - PubMed:22969151, PubMed:24368842
left-to-right
1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+) - PubMed:22969151, PubMed:24368842
left-to-right
(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+) - UniProtKB:O35678
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1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate - PubMed:20079333
left-to-right
1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate - PubMed:20079333
left-to-right
H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2 - PubMed:21049984, PubMed:24368842
left-to-right PubMed:21049984, PubMed:24368842
H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2 - PubMed:24368842
left-to-right
11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy- Delta(12,14)-prostaglandin J2 + glycerol + H(+) - PubMed:24368842
left-to-right
H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha - PubMed:21049984
left-to-right