Brand  (β version)

PDB ID: 3JSG

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Ligands
Code Name Style Show Link
0IN 7-(pyridin-3-ylmethyl)quinolin-8-ol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 3JSG   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution
Release Data : 2009-11-10
Compound :
mol_id molecule chains synonym
1 Macrophage migration inhibitory factor A,B,C MIF, Phenylpyruvate tautomerase, L-dopachrome tautomerase, L-dopachrome isomerase, Glycosylation-inhibiting factor, GIF
ec: 5.3.2.1, 5.3.3.12
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: GLIF, MIF, MMIF
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET22B
Authors : Mclean, L., Zhang, Y.
Keywords : protein-ligand complex, Cytokine, Cytoplasm, Immune response, Inflammatory response, Innate immunity, Isomerase, Phosphoprotein, Secreted
Exp. method : X-RAY DIFFRACTION ( 1.580 Å )
Citation :

Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.

McLean, L.R.,Zhang, Y.,Li, H.  et al.
(2009)  Bioorg.Med.Chem.Lett.  19 : 6717 - 6720

PubMed: 19836948
DOI: 10.1016/j.bmcl.2009.09.106

Reaction

Chain : A, B, C
UniProt : P14174 (MIF_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
3-phenylpyruvate = enol-phenylpyruvate 5.3.2.1 PubMed:11439086
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L-dopachrome = 5,6-dihydroxyindole-2-carboxylate 5.3.3.12 PubMed:17526494
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