Brand  (β version)

PDB ID: 3IU2

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Ligands
Code Name Style Show Link
MYA Tetradecanoyl-CoA PoSSuM
096 (2r)-2-{4-hydroxy-5-methoxy-2-[3-(4-methylpiperazin-1-yl)propyl]phenyl}-3-pyridin-3-yl-1,3-thiazolidin-4-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3IU2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096
Release Data : 2009-09-15
Compound :
mol_id molecule chains synonym
1 Glycylpeptide N-tetradecanoyltransferase 1 A,B Peptide N-myristoyltransferase 1, Myristoyl-CoA:protein N-myristoyltransferase 1, NMT 1, Type I N-myristoyltransferase
ec: 2.3.1.97
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NMT, NMT1
Authors : Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
Keywords : Transferase, N-myristoyltransferase, NMT1, Acyltransferas, Acyltransferase, Phosphoprotein, Structural Genomics, Structural Genomics Consortium, SGC
Exp. method : X-RAY DIFFRACTION ( 1.73 Å )
Citation :

Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096

Qiu, W.,Hutchinson, A.,Wernimont, A.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : P30419 (NMT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein] 2.3.1.97 PubMed:22865860, PubMed:25255805, PubMed:32103017, PubMed:32111831, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952
-
N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] - PubMed:32103017, PubMed:32111831
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