Brand  (β version)

PDB ID: 3IPE

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Ligands
Code Name Style Show Link
JZE 2,2'-{heptane-1,7-diylbis[oxy(3,5-dichlorobenzene-4,1-diyl)imino]}dibenzoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3IPE   PDBj   RCSB PDB   PDBe
Header : HORMONE
Title : Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (7 carbon linker).
Release Data : 2010-11-17
Compound :
mol_id molecule chains synonym
1 Transthyretin A,B Prealbumin, TBPA, TTR, ATTR
fragment: UNP residues 21-147
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Kolstoe, S.E., Wood, S.P., Pepys, M.B.
Keywords : Amyloid, Inhibitor, Palindrome, Amyloidosis, Disease mutation, Gamma-carboxyglutamic acid, Glycoprotein, Hormone, Neuropathy, Secreted, Thyroid hormone, Transport
Exp. method : X-RAY DIFFRACTION ( 1.40 Å )
Citation :

Trapping of palindromic ligands within native transthyretin prevents amyloid formation.

Kolstoe, S.E.,Mangione, P.P.,Bellotti, V.  et al.
(2010)  Proc.Natl.Acad.Sci.USA  107 : 20483 - 20488

PubMed: 21059958
DOI: 10.1073/pnas.1008255107

Reaction

Chain : A, B
UniProt : P02766 (TTHY_HUMAN)
Reaction : -