PDB ID: 3INV
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Code | Name | Style | Show | Link | |
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C50 | 1-[3-(2,3-dichlorophenoxy)propoxy]-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine | PoSSuM | |||
GOL | Glycerol | PoSSuM | |||
NDP | Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate | PoSSuM | |||
UMP | 2'-deoxyuridine 5'-monophosphate | PoSSuM |
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Download interaction data: 3INV
Structure summary
Code : | 3INV PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE/TRANSFERASE | ||||||||||||
Title : | Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH, dUMP AND C-448 ANTIFOLATE | ||||||||||||
Release Data : | 2010-07-28 | ||||||||||||
Compound : |
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Source : |
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Authors : | Chitnumsub, P., Yuvaniyama, J., Yuthavong, Y. | ||||||||||||
Keywords : | DHFR-TS antifolate complex, Methyltransferase, Multifunctional enzyme, NADP, Nucleotide biosynthesis, One-carbon metabolism, Oxidoreductase, Transferase, OXIDOREDUCTASE-TRANSFERASE COMPLEX | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.37 Å ) | ||||||||||||
Citation : |
Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase
Chitnumsub, P.,Yuvaniyama, J.,Vilaivan, T.
et al.
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Reaction
Chain : | A, B | ||||||||||||
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UniProt : | Q27793 (DRTS_TRYCR) | ||||||||||||
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