Brand  (β version)

PDB ID: 3IIQ

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Ligands
Code Name Style Show Link
JZA 4-[(1,1-dioxido-1,2-thiazetidin-2-yl)carbonyl]morpholine PoSSuM
TRT Fragment of triton x-100 PoSSuM
M12 10-methylundecanoic acid PoSSuM
Non-standard Residues
Code Name Show
DSE N-methyl-D-serine
DAL D-alanine
5PG (2s)-(4-hydroxyphenyl)(methylamino)ethanoic acid
Glycosylation
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Modification
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Structure summary

Code : 3IIQ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/ANTIBIOTIC/INHIBITOR
Title : Crystallographic analysis of bacterial signal peptidase in ternary complex with Arylomycin A2 and a beta-sultam inhibitor
Release Data : 2009-09-01
Compound :
mol_id molecule chains synonym
1 SIGNAL PEPTIDASE I A,B SPASE I, LEADER PEPTIDASE I
ec: 3.4.21.89
fragment: UNP RESIDUES 76-323, PERIPLASMIC DOMAIN
mol_id molecule chains
2 ARYLOMYCIN A2 C,D
Source :
mol_id organism_scientific expression_system
1 ESCHERICHIA COLI  (taxid:83333) ESCHERICHIA COLI  (taxid:562)
strain: K-12
gene: LEPB
expression_system_strain: BL21 (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET
mol_id organism_scientific
2 STREPTOMYCES SP.  (taxid:1931)
Authors : Paetzel, M.
Keywords : SER/LYS DYAD, LIPOPEPTIDE, SERINE PROTEASE, BIARYL BRIDGE, MORPHOLINO BETA-SULTAM, ANTIBIOTIC, PEPTIDASE, HYDROLASE-ANTIBIOTIC-INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2 and a Beta-Sultam Inhibitor.

Luo, C.,Roussel, P.,Dreier, J.  et al.
(2009)  Biochemistry  48 : 8976

PubMed: 19655811
DOI: 10.1021/BI9009538

Reaction

Chain : A, B
UniProt : P00803 (LEP_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. 3.4.21.89 -
-