Brand  (β version)

PDB ID: 3I65

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Ligands
Code Name Style Show Link
FMN Flavin mononucleotide PoSSuM
JZ8 5-methyl-7-(naphthalen-2-ylamino)-1h-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium PoSSuM
LDA Lauryl dimethylamine-N-oxide PoSSuM
ORO Orotic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 3I65   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1
Release Data : 2009-07-28
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase homolog, mitochondrial A DHOdehase, Dihydroorotate oxidase
ec: 1.3.3.1
fragment: UNP residues 158-569 with 384-413 deleted
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum 3D7  (taxid:36329) Escherichia coli  (taxid:562)
gene: PFF0160c, Plasmodium falciparum
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28b
Authors : Deng, X., Phillips, M.A.
Keywords : Plasmodium falciparum, dihydroorotate dehydrogenase, triazolopyrimidine, inhibitor, DSM1, FAD, Flavoprotein, Membrane, Mitochondrion, Mitochondrion inner membrane, Oxidoreductase, Pyrimidine biosynthesis, Transit peptide
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.

Deng, X.,Gujjar, R.,El Mazouni, F.  et al.
(2009)  J.Biol.Chem.  284 : 26999 - 27009

PubMed: 19640844
DOI: 10.1074/jbc.M109.028589

Reaction

Chain : A
UniProt : Q08210 (PYRD_PLAF7)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = orotate + a quinol 1.3.5.2 -
-
Cofactor: Evidence: Note:
FMN ECO:0000269 | PubMed:16510978
ECO:0000269 | PubMed:19640844
ECO:0000269 | PubMed:20702404
Binds 1 FMN per subunit.