Het-PDB Navi2 (PDB: 3HY9)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
CA	Calcium ion	PoSSuM
098	(3r)-N~2~-(cyclopropylmethyl)-N~1~-hydroxy-3-(3-hydroxybenzyl)-N~4~-[(1s,2r)-2-hydroxy-2,3-dihydro-1h-inden-1-yl]-L-aspartamide	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3HY9

Code :

3HY9 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound

Release Data :

2009-07-07

Compound :

mol_id	molecule	chains
1	Catalytic Domain of ADAMTS-5	A,B
	ec: 3.4.24.- fragment: Catalytic Domain (UNP residues 262 to 480) mutation: L282K

Source :

mol_id	organism_scientific	expression_system
1	Homo sapiens (taxid:9606)	Escherichia coli (taxid:562)
	gene: ADAMTS-5 expression_system_strain: MON208 expression_system_vector_type: plasmid expression_system_plasmid: PPHA79257

Authors :

Shieh, H.-S., Williams, J.M., Caspers, N., Mathis, K.J., Tortorella, M.D., Tomasselli, A.

Keywords :

alpha/beta structure, central five stranded beta-sheet, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.02 Å )

Citation :

Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors

Tortorella, M.D.,Tomasselli, A.G.,Mathis, K.J. et al.
(2009) J.Biol.Chem. 284 : 24185 - 24191

PDB ID: 3HY9