Brand  (β version)

PDB ID: 3HY9

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CA Calcium ion PoSSuM
098 (3r)-N~2~-(cyclopropylmethyl)-N~1~-hydroxy-3-(3-hydroxybenzyl)-N~4~-[(1s,2r)-2-hydroxy-2,3-dihydro-1h-inden-1-yl]-L-aspartamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3HY9   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound
Release Data : 2009-07-07
Compound :
mol_id molecule chains
1 Catalytic Domain of ADAMTS-5 A,B
ec: 3.4.24.-
fragment: Catalytic Domain (UNP residues 262 to 480)
mutation: L282K
Source :
mol_id organism_scientific expression_system
1 Homo sapiens  (taxid:9606) Escherichia coli  (taxid:562)
gene: ADAMTS-5
expression_system_strain: MON208
expression_system_vector_type: plasmid
expression_system_plasmid: PPHA79257
Authors : Shieh, H.-S., Williams, J.M., Caspers, N., Mathis, K.J., Tortorella, M.D., Tomasselli, A.
Keywords : alpha/beta structure, central five stranded beta-sheet, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.02 Å )
Citation :

Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors

Tortorella, M.D.,Tomasselli, A.G.,Mathis, K.J.  et al.
(2009)  J.Biol.Chem.  284 : 24185 - 24191

PubMed: 19586907
DOI: 10.1074/jbc.M109.029116

Reaction

Chain : A, B
UniProt : Q9UNA0 (ATS5_HUMAN)
Reaction : -
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:18042673
Binds 1 zinc ion per subunit.