Het-PDB Navi2 (PDB: 3HUM)

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Ligands
Code	Name		Style	Show	Link
CEW	(2r)-2-[(1r)-1-({[(2r)-2-amino-2,3-dihydro-1,3-thiazol-4-yl](methoxyimino)acetyl}amino)-2-oxoethyl]-5-methyl-3,6-dihydro-2h-1,3-thiazine-4-carboxylic acid				PoSSuM

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Download interaction data: 3HUM

Code :

3HUM PDBj RCSB PDB PDBe

Header :

HYDROLASE/Antibiotics

Title :

Crystal structure of Penicillin binding protein 4 from Staphylococcus aureus COL in complex with Cefotaxime

Release Data :

2009-11-10

Compound :

mol_id	molecule	chains
1	Penicillin-binding protein 4	A,B
	ec: 3.4.16.4 mutation: T189S

Source :

mol_id	organism_scientific	expression_system
1	Staphylococcus aureus (taxid:93062)	Escherichia coli (taxid:562)
	strain: COL gene: pbp4 expression_system_strain: BL21DE3 expression_system_vector_type: Plasmid expression_system_plasmid: pET28a

Authors :

Navratna, V., Gopal, B.

Keywords :

Penicillin binding protein 4, Cefotaxime, beta-lactamase, Serine type D-Ala, D-Ala-carboxypeptidase, Antibiotics, HYDROLASE-Antibiotics complex

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

Molecular basis for the role of Staphylococcus aureus Penicillin Binding Protein 4 in antimicrobial resistance

Navratna, V.,Nadig, S.,Sood, V. et al.
(2009) J.Bacteriol.

PDB ID: 3HUM