Brand  (β version)

PDB ID: 3HL5

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
9JZ (3s)-1-{(2s)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-3-methyl-N-(2-pyrimidin-2-ylphenyl)-L-prolinamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3HL5   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal structure of XIAP BIR3 with CS3
Release Data : 2009-06-16
Compound :
mol_id molecule chains synonym
1 Baculoviral IAP repeat-containing protein 4 A,B E3 ubiquitin-protein ligase XIAP, Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP
ec: 6.3.2.-
fragment: BIR3, UNP residues 256-346
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: API3, BIRC4, IAP3, XIAP
expression_system_strain: BL-21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET15b
Authors : Hymowitz, S.G.
Keywords : BIR, IAP, apoptosis, small molecule drug discovery, structure-based drug design, Ligase, Metal-binding, Phosphoprotein, Protease inhibitor, Thiol protease inhibitor, Ubl conjugation pathway, Zinc-finger
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

Ndubaku, C.,Varfolomeev, E.,Wang, L.  et al.
(2009)  Acs Chem.Biol.  4 : 557 - 566

PubMed: 19492850
DOI: 10.1021/cb900083m

Reaction

Chain : A, B
UniProt : P98170 (XIAP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:19473982, PubMed:20154138, PubMed:21931591, PubMed:22304967, PubMed:22607974, PubMed:30026309
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