PDB ID: 3H82
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Structure summary
Code : | 3H82 PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSCRIPTION | ||||||||||||||||||||||||
Title : | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS020 | ||||||||||||||||||||||||
Release Data : | 2010-01-12 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Key, J.M., Scheuermann, T.H., Anderson, P.C., Daggett, V., Gardner, K.H. | ||||||||||||||||||||||||
Keywords : | PAS domain, heterodimer, protein ligand complex., Activator, Angiogenesis, Congenital erythrocytosis, Developmental protein, Differentiation, Disease mutation, DNA-binding, Hydroxylation, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Ubl conjugation, Alternative splicing, Polymorphism | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.50 Å ) | ||||||||||||||||||||||||
Citation : |
Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B
Key, J.,Scheuermann, T.H.,Anderson, P.C.
et al.
PubMed: 19950993 |
Reaction
Chain : | B |
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UniProt : | P27540 (ARNT_HUMAN) |
Reaction : | - |
Chain : | A |
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UniProt : | Q99814 (EPAS1_HUMAN) |
Reaction : | - |