Brand  (β version)

PDB ID: 3GWS

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Ligands
Code Name Style Show Link
T3 3,5,3'triiodothyronine PoSSuM
Non-standard Residues
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CAS S-(dimethylarsenic)cysteine
Glycosylation
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Structure summary

Code : 3GWS   PDBj   RCSB PDB   PDBe
Header : Hormone activator
Title : Crystal Structure of T3-Bound Thyroid Hormone Receptor
Release Data : 2009-04-28
Compound :
mol_id molecule chains synonym
1 Thyroid hormone receptor beta X Nuclear receptor subfamily 1 group A member 2
fragment: Ligand Binding Domain (UNP residues 202 to 460)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: THRB, ERBA2, NR1A2, THR1
Authors : Nascimento, A.S., Dias, S.M.G., Nunes, F.M., Aparicio, R., Polikarpov, I., Baxter, J.D., Webb, P.
Keywords : Thyroid hormone receptor, T3, hinge, Alternative splicing, Deafness, Disease mutation, DNA-binding, Metal-binding, Nucleus, Polymorphism, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger, Hormone activator
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function

Nascimento, A.S.,Dias, S.M.G.,Nunes, F.M.  et al.
(2006)  J.Mol.Biol.  360 : 586 - 598

PubMed: 16781732
DOI: 10.1016/j.jmb.2006.05.008

Reaction

Chain : X
UniProt : P10828 (THB_HUMAN)
Reaction : -